Venetica is a game for Windows and the XBox 360, currently being developed by Deck13 and published by DTP Entertainment. Due for release later this year the developer has published an insightful video into the making of the game, including building and modelling the environment:
The official trailer is embedded below:
The mix of the iconic architecture of Venice in the game engine is quite striking...
Full details at http://www.venetica-game.com/